Press releases

· Coming Phase I/IIa basket trial planned to include five select cancer indications
· Study will apply Curasight’s uPAR theranostic platform approach combining diagnosis (uTRACE[®]) and therapy (uTREAT[®])
· First patients expected to be dosed in the beginning of 2025 with expected first efficacy data in 2025.

Copenhagen, Denmark, 13 February 2024 - Curasight A/S ("Curasight" or the “Company" – TICKER: CURAS) announces today that it is accelerating and expanding its clinical therapeutic strategy with the addition of a new Phase I/IIa trial to include a total of five cancer indications in a so called basket trial design. The trial will investigate Curasight’s theranostic (therapeutics/diagnostics) approach by testing the diagnostic platform uTRACE[® ]and the treatment platform uTREAT[®] in brain cancer (Glioblastoma), neuroendocrine tumors (NET), head-and-neck cancer (HNSCC), non-small cell lung cancer (NSCLC), and pancreatic cancer. To strengthen the Company’s capital structure and secure funding for the acceleration of clinical activities, Curasight intends to launch a rights issue during the first quarter of 2024. Details of the rights issue are to be announced in a separate press release immediately following this release.

· USD 500.000 payment is the first milestone under the global license and collaboration agreement for the development and commercialization of uTRACE[®] for use in prostate cancer between Curasight A/S and Curium Inc.
· Milestone relates to the validation of GMP manufacturing of finished product and illustrates progress in the development plan for uTRACE[®] PET imaging technology
· Under the agreement signed in 2023 Curasight is eligible to receive up to mUSD 70 in development milestones plus additional commercial milestones and double-digit royalties on sales upon commercialization

Copenhagen, January 22, 2024 - Curasight A/S (“Curasight” or “the Company” – TICKER: CURAS) today announced the achievement of the first milestone under the agreement with Curium inc., to develop Curasight’s uTRACE[®] PET imaging technology for the improved diagnosis of prostate cancer. The milestone relates to the validation of GMP manufacturing of finished product.

· Company on track to dose first patient in 2Q 2024
· CTA marks progress in development of uTRACE[®] in prostate cancer under the collaboration between Curasight and Curium

Copenhagen, December 18, 2023 - Curasight A/S (“Curasight” or “the Company” – TICKER: CURAS) today announced submission of clinical trial application (CTA) to the European Medicines Agency (EMA) for the investigation of uTRACE® in a phase 2 trial as a non-invasive alternative or supplement to traditional biopsies in prostate cancer patients in active surveillance.

· Phase 2 study is part of the collaboration between Curasight and Curium announced earlier this year
· Appointment of clinical CRO marks further step in progress in development of uTRACE as a potential new diagnostic solution for prostate cancer

Copenhagen, December 13, 2023 - Curasight A/S (“Curasight” or “the Company” – TICKER: CURAS) today announced it has signed an agreement with ABX-CRO, an experienced international clinical research organization serving the pharmaceutical industry, to run the phase 2 study investigating uTRACE[®] in improving the diagnosis of prostate cancer.

Copenhagen, Denmark, 24 November 2023 - Curasight A/S ("Curasight" or the “Company" - TICKER: CURAS) hereby announces that CEO Ulrich Krasilnikoff and CSO professor Andreas Kjær will present the company’s Interim Report Q3 2023 at HC Andersen Capital and Stokk.io

Business Highlights during the third quarter 2023

· Encouraging preclinical data using uTREAT[®] in non-small cell lung cancer
· Positive Phase II data reported from uTRACE[®] in brain cancer
· Advancing the theranostics by ongoing momentum in development pipeline with data and regulatory progress 

Copenhagen, Denmark, 23 November 2023 - Curasight A/S (“Curasight” or “the Company” – TICKER: CURAS) hereby publishes the interim report for the period January 1 – September 30, 2023. The interim report is available as an attached file to this release and on the Company’s website. Below is a summary of the report.

· Preclinical studies show uTREAT[®] effective in treating non-small cell lung cancer (NSCLC)

· Data follows recent announcement of positive preclinical results within glioblastoma and supports hypothesis that uTREAT[®] has treatment potential in additional solid tumors

· Data highlights potential of company’s uPAR theranostic platform to combine diagnosis (uTRACE[®]) with more gentle and targeted treatment (uTREAT[®])

Copenhagen, October 18, 2023 - Curasight A/S (“Curasight” or “the Company” – TICKER: CURAS) is pleased to announce preclinical data demonstrating preclinical proof of concept of uTREAT[®] in treating non-small cell lung cancer (NSCLC). Today’s news follows the announcement earlier this year of positive preclinical results of uTREAT[®] in glioblastoma.

Oral presentation gives more details from the Phase II data where topline results were released on June 29, 2023.

Investigators for the Phase II trial concluded that:

· The majority of the glioma patients displayed uPAR-positive tumors
· High uPAR expression is significantly correlated with a worse outcome
· The study demonstrates the potential of uPAR-targeted radionuclide therapy (uTREAT®) for patients with high-grade gliomas

Copenhagen, Denmark, September 14, 2023 - Curasight A/S ("Curasight" or the “Company" - TICKER: CURAS) announces today that the previously announced results from the investigator-initiated phase II study using uPAR-PET (uTRACE®) in primary brain cancer have been presented in an oral presentation at the World Molecular Imaging Congress (WMIC) 2023 in Prague.

Copenhagen, Denmark, 25 August 2023 - Curasight A/S ("Curasight" or the “Company" - TICKER: CURAS) hereby announces that CEO Ulrich Krasilnikoff and CSO professor Andreas Kjær will present the company’s Interim Report Q2 2023 at HC Andersen Capital 30 August and the clinical progress at HC Andersen Capital Life Science seminar, 31 August 2023. 

Copenhagen, Denmark, 24 August 2023 - Curasight A/S (“Curasight” or “the Company” – TICKER: CURAS) hereby publishes the interim report for the period January 1 – June 30, 2023. The interim report is available as an attached file to this release and on the Company’s website. Below is a summary of the report.