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Curasight

Clinical studies

Safety, Dosimetry, and Tumor Detection Ability of 68Ga-NOTA-AE105: First-in-Human Study of a Novel Radioligand for uPAR PET b Imaging
Skovgaard D, Persson M, Brandt-Larsen M, Christensen C, Madsen J, Klausen TL, Holm S, Andersen FL, Loft A, Berthelsen AK, Pappot H, Brasso K, Kroman N, Højgaard L, Kjaer A.
J Nucl Med 2017; 58: 379-386
PMID: 27609788 

First-in-human uPAR PET: Imaging of Cancer Aggressiveness
Persson M, Skovgaard D, Brandt-Larsen M, Christensen C, Madsen J, Nielsen CH, Thurison T, Klausen TL, Holm S, Loft A, Berthelsen AK, Ploug M, Pappot H, Brasso K, Kroman N, Højgaard L, Kjaer A. 
Theranostics 2015; 5: 1303-16
PMID: 26516369

Preclinical studies

Improved positron emission tomography imaging of glioblastoma cancer using novel 68Ga-labeled peptides targeting the urokinase-type plasminogen activator receptor (uPAR)
Loft MD, Sun Y, Liu C, Christensen C, Huang D, Kjaer A, Cheng Z. 
Amino Acids 2017; 49: 1089-1100
PMID: 28316028

Urokinase-Type Plasminogen Activator Receptor as a Potential PET Biomarker in Glioblastoma
Persson M, Nedergaard MK, Brandt-Larsen M, Skovgaard D, Jørgensen JT, Michaelsen SR, Madsen J, Lassen U, Poulsen HS, Kjaer A.
J Nucl Med 2016; 57: 272-8
PMID: 26429955

Dosimetry of 64Cu-DOTA-AE105, a PET tracer for uPAR imaging
Persson M, El Ali HH, Binderup T, Pfeifer A, Madsen J, Rasmussen P, Kjaer A.
Nucl Med Biol 2014; 41: 290-5
PMID: 24533988

Improved PET imaging of uPAR expression using new (64)Cu-labeled cross-bridged peptide ligands: comparative in vitro and in vivo studies
Persson M, Hosseini M, Madsen J, Jørgensen TJ, Jensen KJ, Kjaer A, Ploug M.
Theranostics 2013; 3: 618-32
PMID: 24052804

First (18)F-labeled ligand for PET imaging of uPAR: in vivo studies in human prostate cancer xenografts
Persson M, Liu H, Madsen J, Cheng Z, Kjaer A. 
Nucl Med Biol 2013; 40: 618-24
PMID: 23602763

Quantitative PET of human urokinase-type plasminogen activator receptor with 64Cu-DOTA-AE105: implications for visualizing cancer invasion
Persson M, Madsen J, Østergaard S, Jensen MM, Jørgensen JT, Juhl K, Lehmann C, Ploug M, Kjaer A.
J Nucl Med 2012; 53: 138-45
PMID: 22213823

68Ga-labeling and in vivo evaluation of a uPAR binding DOTA- and NODAGA-conjugated peptide for PET imaging of invasive cancers
Persson M, Madsen J, Østergaard S, Ploug M, Kjaer A. 
Nucl Med Biol 2012; 39: 560-9
PMID: 22172391